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William H. Macy (1950 - )
- Homicide (1991) [Tim Sullivan]: Shot repeatedly by Ving Rhames; he dies after talking to Joe Mantegna.
- The Client (1994) [Dr. Greenway]: Killed (off-screen) presumably by a mob assassin (possibly Kim Coates).
- Evolver (1995) [Evolver (voice)]: Voicing a robot; 'he' is destroyed in an explosion when Ethan Embry shoots him repeatedly with his own laser.
- Air Force One (1997) [Major Caldwell]: Shot repeatedly in the chest by Xander Berkeley in a double-cross onboard Air Force One as Harrison Ford looks on in shock.
- Boogie Nights (1997) [Little Bill]: Commits suicide by shooting himself in the mouth after shooting Nina Hartley during a New Year's party.
- Psycho (1998) [Milton Arbogast]: Slashed to death by Vince Vaughn on a staircase (who cuts his face continuously), causing William to fall down a flight of stairs, with Vince then stabbing his body repeatedly (off-screen). (See also Martin Balsam in the 1960 version.)
- Panic (2000) [Alex]: Shot in the stomach by Miguel Sandoval after William shoots his father (Donald Sutherland).
- The Lincoln Lawyer (2011) [Frank Levin]: Shot in the head and chest (along with his dog) by Frances Fisher with Matthew McConaughey’s Colt Woodsman pistol. His body is later seen when Matt enters William’s home and discovers the police (including Bryan Cranston) investigating.
- Stealing Cars (2015) [Philip Wyatt]: Killed in a car crash (off-screen); the scene ends just before the car William is inside is hit by another vehicle and his death is revealed when John Leguizamo discusses it with his son (Emory Cohen).
- In the Shadow of Evil (1995; TV Movie) [Dr. Frank Teague]: Killed (I recall shot) by Treat Williams, who frames him for Treat’s crimes.
- Nightmares and Dreamscapes: Umney's Last Case (2006) [Clyde Umney/Sam Landrey/George Demmick]: Playing multiple roles, "George Demmick" commits suicide by taking an overdose of medication.
- Mr. Felicity Huffman