What Is It? (2005)
Director: Crispin Glover
Note: This film is only shown at special screenings as part of Crispin Glover's personal-appearance tours; he currently has no plans to release it on DVD.
What Is It? is a bewildering, unnerving, surreal, blackly comic film from the visionary mind of Crispin Glover that tells the inner and outer struggles of a young man facing villains and demons on multiple planes.
Official page from Crispin Glover's website