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Vincent D'Onofrio (1959 - )
- Full Metal Jacket (1987) [Pvt. Leonard 'Gomer Pyle' Lawrence]: Commits suicide by shooting himself in the mouth after shooting R. Lee Ermey in the bathroom, while Matthew Modine looks on in shock.
- Naked Tango (1991) [Cholo]: Shot to death by police while dancing one last dance with the mortally wounded Mathilda May. (Thanks to Debbe)
- The Player (1992) [David Kahane]: Drowned by Tim Robbins in a puddle in an alley (during an argument).
- Salt on Our Skin (1992) [Gavin]: Dies of cancer (off-screen). (Thanks to Debbe)
- Ed Wood (1994) [Orson Welles]: Dies (off-screen) of a heart attack, several years after the movie ends.
- Strange Days (1995) [Officer Burton Steckler]: Shot repeatedly by police when he aims his gun at Ralph Fiennes and Angela Bassett in a crowded city square.
- Feeling Minnesota (1996) [Sam Clayton]: Suffocated by Dan Aykroyd, while his brother (Keanu Reeves) and Cameron Diaz look on in horror. (Thanks to Jesse)
- The Whole Wide World (1996) [Robert E. Howard]: Commits suicide (off-screen) by shooting himself in the head; we only see a scene of Renee Zellweger being informed of his death.
- Men in Black (1997) [Edgar/The Bug]: Playing both Edgar and the alien insect posing as him, "Edgar" is flayed by the Bug and his skin used as a disguise; "The Bug" is blown in half by Tommy Lee Jones before being shot dead by Linda Fiorentino.
- The Velocity of Gary (1998) [Valentino]: Dies of AIDS-related complications in the hospital, shortly after Salma Hayek and Thomas Jane take a break from their bedside vigil. (Thanks to Megan and Jesse)
- Spanish Judges (1999) (Ruthless Behaviour) [Max]: Shot repeatedly in the chest and stomach by Matthew Lillard, then is impaled on a large sculpture when he falls back.
- The Thirteenth Floor (1999) [Jason Whitney/Jerry Ashton]: Playing a dual role in two virtual-reality planes, "Jason" (in Jerry's role) is run over by a car in the 1930s simulation. "Jerry" (now in Jason's role) is shot repeatedly in the head and chest by Craig Bierko. (Thanks to Betty and PortsGuy)
- The Cell (2000) [Carl Rudolph Stargher]: Dies in the real world when Jennifer Lopez drowns his mental self (played by Vincent and Jake Thomas) at his own request.
- Steal This Movie! (2000) [Abbie Hoffman]: Died on April 12 1989.
- Impostor (2001) [Major D.H. Hathaway]: Killed in an hydrogen/nuclear explosion (along with all his cohorts) when Gary Sinise's android duplicate self-destructs (after Vincent discovers the real Gary Sinise dead in a space craft). (Thanks to Jesse)
- The Salton Sea (2002) [Pooh-Bear]: Shot in the back of the head by Anthony LaPaglia after Anthony comes up behind the oblivious Vincent while Vincent is preparing some methedrine.
- Brooklyn's Finest (2009) [Carlo]: Shot in the head by Ethan Hawke as they are sitting in a car (with his body later seen as Ethan robs him). (Thanks to Tommy)
- Staten Island (2009) [Parmie Tarzo]: Shot to death by Seymour Cassel. (Thanks to Nilescu)
- Kill the Irishman (2011) [John Nardi]: Dies by being near the blast of his car exploding. Dies while talking to Ray Stevenson.
- Chained (2012) [Bob]: Stabbed in the throat by Eamon Farren with his own knife after Vincent attempts to kill Conor Leslie.
- Fire with Fire (2012) [David Hagan]: Falls to his death out the top floor of a building after being shot multiple times by Rosario Dawson who later shot at the gas canister engulfing him in flames (on top of having a fire axe thrown into his chest by Josh Duhamel).
- Escape Plan (2013) [Lester Clark]: Dies (off-screen) of asphyxiation after being locked in his car in a shipping container on a ship by 50 Cent. His death was confirmed in Escape Plan: The Extractors (2019), and his son: Devon Sawa wants revenge on Sylvester Stallone for his death.
- Broken Horses (2015) [Julius Hench]: Burned to death/killed in an explosion along with his remaining cohorts (including Chad Bishop, Peter Vinding, Wes Chatham, Jeremy Luke, Steve Luna, AJ Meijer, Juan Riedinger and David Namminga) when Chris Marquette ignites the gas leaking from an oven by throwing a lit match into it, sacrificing himself so his brother (Anton Yelchin) and María Valverde can escape
- Jurassic World (2015) [Vic Hoskins]: Mauled to death by a velociraptor inside a laboratory.
- Pelé: Birth of a Legend (2016)
- The Magnificent Seven (2016) [Jack Horne]: Shot to death with arrows by Jonathan Joss as Luke Grimes watches on.
- Rings (2017) [Galen Burke]: Killed by his daughter (Bonnie Morgan)'s ghost, after she crawls out of Matilda Anna Ingrid Lutz's phone (having restored her father's vision).
- CHiPs (2017) [Ray Kurtz]: Accidentally shot in the head when he opens fire on Dax Shepard with one of the bullets being deflected off his titanium arm plates.
- El Camino Christmas (2017) [Officer Carl Hooker]: Shot in the heart by Luke Grimes immediately after shooting Luke.
- Miami Vice: The Afternoon Plane (1987) [Leon Wolf]: Shot in the back with a Sub-Machine gun by Maria McDonald. (Thanks to Robert)
- Homicide: Life on the Street: The Subway (1997) [John Lange] Run over by a subway train after being pushed onto the tracks; he is not instantly killed, and the entire episode deals with his ordeal being pinned under the subway car (as any attempt to free him will only kill him sooner). I believe his actual death occurred off-screen (but it's been so long since I've seen the episode that I can't recall for certain.)
- The Taking of Pelham One Two Three (1998 TV) [Mr. Blue]: Commits suicide by electrocuting himself on the subway's third rail, rather than be arrested by Edward James Olmos. (I haven't seen this version, but I have seen Robert Shaw's death in the 1974 version.) (Thanks to Debbe)
- Sherlock (2002 TV) [Moriarty]: Stabbed in the chest by James D'Arcy.
- Godfather of Harlem (2019 series)
- Ex-husband of Greta Scacchi.