Male Deaths[]
- Caleb Alexander Smith [Seth] (1.03 Contain the Flame - Died of smoke inhalation)
- Benjamin Thys [Marshall] (1.05 Shock to the System - Died of internal injuries after being electrocuted)
- Sam Anderson [Elliot] (2.13 The Dark Night)
- Brett Tucker [Fire Chief Lucas Ripley] (2.15 Always Ready)
- Alberto Frezza [Ryan Tanner] (3.03 Eulogy - Died off-screen of a gunshot wound sustained in the previous episode)
- JF Davis [Martin] (3.03 Eulogy)
- Steven Allerick [Marco] (3.04 House Where Nobody Lives)
- Rigo Sanchez [Rigo Vasquez] (3.09 Poor Wandering One - Died of a pulmonary embolism following injuries sustained while on duty in a previous episode 3.07)
- Miguel Sandoval [Pruitt Herrera] (3.12 I’ll Be Seeing You)
- Okieriete Onaodowan [Dean Miller] (5.05 Things We Lost in The Fire)
Female Deaths[]
- Vanessa Marano [Molly] (2.01 No Recovery)
- Trinecia Moore-Pernell [Claire Sullivan] (2.05 Do a Little Harm... - Died of her injuries after a car accident, her death is shown in flashbacks)
- Leah Lewis [Shannon] (2.08 Crash and Burn - Died of cardiac arrest after a car accident, then the ambulance she was in got blown off a cliff)
- Ann Cusack [Joan] (3.01 I Know This Bar)
- Phylicia Rashad [Pilar] (3.06 Ice Ice Baby)