Director: Nimrod Antal
- Mahershalalhashbaz Ali [Mombasa]
- Louis Ozawa Changchien [Hanzo]
- Laurence Fishburne [Noland]
- Walton Goggins [Stans]
- Topher Grace [Edwin]
- Derek Mears [Classic Predator]
- Brian Steele [Berserker Predator]
- Oleg Taktarov [Nikolai]
- Danny Trejo [Cuchillo]
- Laurence Fishburne filmed for just two days.
- Adrien Brody put on twenty-five pounds of muscle for his role.
- The original script contained cameo appearances by Dutch (Arnold Schwarzenegger) and Michael Harrigan (Danny Glover), the protagonists of the previous Predator films. However, these appearances were ultimately cut out.
- Robert Rodriguez intended this film to be part of the "Predator" franchise, and not the "Alien Vs. Predator" franchise.
- Danny Trejo's character is named Cuchillo. "Cuchillo" is Spanish for "knife". Many of Trejo's characters in Robert Rodriguez movies have been named after knives or sharp instruments: Machete in Spy Kids (2001), Spy Kids 2: Island of Lost Dreams (2002), and Spy Kids 3: Game Over (2003); Razor Charlie and Razor Eddie in From Dusk Till Dawn (1996), From Dusk Till Dawn 2: Texas Blood Money (1999), and From Dusk Till Dawn 3: The Hangman's Daughter (1999), Navajas (Spanish for "blades") in Desperado (1995), and he also plays another character called Machete in Machete (2010) and its sequels.
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