Mary McDonnell (1952 - )
- Independence Day (1996) [First Lady Marilyn Whitmore]: Dies (off-screen) of internal bleeding due to injuries from a helicopter crash; we last see her in a hospital bed talking to Bill Pullman. Her death is confirmed in subsequent dialogue. (Thanks to Paul, Neil, Drew and Sheena)
- Donnie Darko (2001) [Rose Darko]: Killed in a plane crash, along with her daughter (Daveigh Chase) and everyone else on board, when the plane hits turbulence from the time tunnel; her son (Jake Gyllenhaal) later alters the timeline and prevents her death. (Thanks to Tommy)
- Scream 4 (Scre4m) (2011) [Kate Roberts]: Stabbed in the back through the mail slot by Ghostface (Emma Roberts) while she is sitting against the door, as Neve Campbell looks on helplessly. (Thanks to Steve, Andrew, Nyk and Matthew)
- Touched by an Angel: Minute By Minute (2002) [Sister Theodore]: Saves the students of a high school when she pulls the fire alarm before bombs that Jonah Rooney planted detonate. Having already been wounded by Jonah previously in the episode, she is unable to leave the school in time to save herself.
- Battlestar Galactica: Daybreak Part 2 (2009) [President Laura Roslin]: Dies of cancer with Edward James Olmos by her side. (Thanks to Alex)
- Major Crimes: Conspiracy Theory Part 4 (2017) [Commmader Sharon Raydor]: Dies in the hospital of a heart attack after collapsing while interrogating a suspect in the interrogation room.