Around the year 1892, a legendary Army captain (Joseph Blocker) reluctantly agrees to escort a Cheyenne chief (Yellow Hawk) and his family through dangerous territory.
- Paul Anderson [Corp. Tommy Thomas]
- Scott Anderson [Muny (Buffalo Hunter)]
- Adam Beach [Black Hawk]
- Ryan Bingham [Sgt. Paul Malloy]
- Richard Bucher [Ezekiel Lounde]
- Ben Foster [Sgt. Charles Wills]
- Rory Cochrane [Sgt. Thomas Metz]
- Brian Duffy [Silas Loude]
- Dicky Eklund Jr. [Hatchet Face (Buffalo Hunter)]
- Jesse Plemons [Lt. Rudy Kidder]
- Timothée Chalamet [Pvt. Philippe "Frenchie" DeJardin]
- David Midthunder [Buffalo Man]
- Luce Rains [Virgil Loude]
- Scott Shepherd [Wesley Quaid]
- Boots Southerland [Outlaw (Buffalo Hunter)]
- Wes Studi [Chief Yellow Hawk]
- Scott Wilson [Cyrus Lounde]
- Tanaya Beatty [Living Woman]
- Ava Cooper [Lucy Quaid]
- Stella Cooper [Sylvie Quaid]
- Q'orianka Kilcher [Elk Woman]
- The film was shot in chronological order.
- Rory Cochrane and Jesse Plemons both starred in Black Mass (2015), also directed by Scott Cooper.
- Christian Bale, Q'orianka Kilcher and Wes Studi also starred in The New World (2005).
- Rosamund Pike revealed in an interview that she and Christian Bale barely spoke during filming outside of shooting their scenes, saying that Bale "would keep a distance. Our characters in 'Hostiles' are quite dysfunctional but have this profound connection that we let happen without ever really talking about it".
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