Brent Spiner (1949- )
- Star Trek Generations (1994) [Lt. Commander Data]: Killed along with the rest of the Enterprise crew when the planet they had crash-landed on is destroyed by a shockwave caused when Malcolm McDowell fires a missile into the sun: their death are undone when Patrick Stewart goes back in time and stops Malcolm.
- Independence Day (1996) [Dr. Brackish Okun]: "Killed" (or at least clinically) when the alien he's operating on attacks and strangles him by the throat with its tentacle, subsequently taking over his body to communicate; Robert Loggia, Adam Baldwin and Bobby Hosea kill the extraterrestrial. (according to Spiner, a scene where Baldwin checks his pulse and says "He's dead, sir" was filmed but then cut out of the movie; the director's commentary notes he was just knocked out and in a coma, and sequel Independence Day: Resurgence proves that by showing Spiner remains in a 20-year coma; but this is still listed since this was originally intended as a death scene.)
- South Park: Bigger Longer & Uncut (1999; animated) [Conan O'Brien]: Commits suicide by jumping through the window of the studio landing on a car below. (Played for comic effect.)
- Star Trek Nemesis (2002) [Lt. Commander Data / B-4]: Playing a dual role, "Data" is killed in an explosion when he sacrifices himself by firing his phaser into the radiation core of Tom Hardy's ship, causing it to explode. ("B-4" survives the film, with "Data" having implanted his memories into him)
- The Midnight Man (2016) [Ezekiel]: Shot to death by Max Adler, while Will Kemp looks on.
- Star Trek: The Next Generation: Brothers (1990) [Lt. Commander Data / Lore / Dr. Noonian Soong]: Playing a triple role as the android "Data", his evil twin "Lore", and their human creator, "Dr. Noonian Soong", "Dr. Soong" is fatally injured when "Lore" tosses him against a table with equipment (though he was already dying of old age/natural causes); he dies shortly afterwards while talking to "Data".
- Star Trek: The Next Generation: Cause and Effect (1992) [Lt. Commander Data]: Killed in an explosion, along with the rest of the crew, when the Enterprise collides with Kelsey Grammer's ship; due to a time-loop, this is repeated several times until Brent succeeds in preventing the collision.
- Star Trek The Next Generation: Descent Part II (1993) [Lt. Commander Data / Lore] Playing a dual role, "Lore" is disassembled (off-screen) after being shot with a phaser and deactivated by "Data".
- Star Trek: The Next Generation: All Good Things... (1994) [Lt. Commander Data]: Portraying a triple role of "Data" from the past, present, and future, each is killed when the Enterprise of each point in time converge and are destroyed while collapsing the anti-time anomaly. Everyone's deaths are undone when John de Lancie resets the timeline.
- Deadly Games: The Practical Joker (1995) [Danny Schlecht]: Playing a dual role as his alter ego, he is vaporized when Christopher Lloyd ejects a VHS of his programming, wiping him out of existence.
- Alphas: Blind Spot (2011) [Dr. Graham Kern]: Stabbed in the side of the neck with a glass shard by Rebecca Mader.
- The Blacklist: The Architect (No. 107) (2017) [The Architect]: Dies in an explosion when Amir Arison Shot a high powered rifle blast into his SUV, causing it to explode.
- Outcast: This is How it Ends (2017) [Sidney]: Suffocated by Phillip Glenister while Patrick Fugit tries to stop him. His final words are "You Lost Kyle" as he dies.
- Star Trek: Picard (2020) [B-4, Lt. Commander Data, Dr. Altan Soong]: Playing a triple role. "B-4" dies off-screen between Star Trek Nemesis and the present day, as his primitive positronic network was unable to support Data's neural network anbd collapsed. His remains are kept disassembled at the Daystrom Institute, and are shown to Patrick Stewart by Alison Pill. "Data" is revealed to have been resurrected by "Altan" and John Ales, and is living in a simulated reality. He dies again when Patrick shuts down the simulacrum at "Data's" request. "Altan" survives the first season (B-4's remains are props and not actually portrayed by Spiner. However because the role was originated by Spiner in Star Trek Nemesis it is listed here to record his death between the film and series).
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